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Synthesis of the Bioactive Benzochromenes Pulchrol and ...

The parasites Leshmania mexicana and Trypanosoma cruzi cause serious health problems, and few efficient treatments are available. Recently, the two benzochromenes pulchrol (1 ) and pulchral (2 ) were reported from the roots of Bourreria pulchra, and especially 1 but also 2 was found to be active towards the parasites.In this paper, we present a total synthesis of 1 and 2 to facilitate their ...

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3-Amino-1-phenyl-1H-benzo[f]chromene-2 .Traduire cette page

3-Amino-1-phenyl-1H-benzo[f]ch romene-2-carbonitrile. Molecular Formula C 20 H 14 N 2 O; Average mass 298.338 Da; Monoisotopic mass 298.110626 Da; ChemSpider ID 2114805; More details: Systematic name. 3-Amino-1-phenyl-1H-benzo[f]chromene-2-c arbonitrile. SMILES. c1ccc(cc1)C2c3c4cccc c4ccc3OC(=C2C#N)N Copy. Std. InChi. InChI=1S/C20H14N2O/c 21-12-16-18(14-7-2 .

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Aqua mediated synthesis of substituted 2-amino-4H ...

General procedure for the synthesis of 2-amino-3-cyano-4-substituted-4H-benzo[e]chromene derivatives (3a–d) An equimolar mixture of aldehyde ( 1a–d ), malononitrile, and β-naphthol in 10 ml saturated solution of 10 ml K 2 CO 3 was taken in an Erlenmeyer flask and subjected to MWI.

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Synthesis of New 2-Phenylamino-4H-chromene-3-carbonitrile ...

1. Introduction. During the two last decades, the 2-amino-4H-chromene moieties emerged to be a promising platform in new chromene and benzo chromene derivatives, which exhibit a wide range of biological and pharmacological activities.For examples, Crolibulin TM (EPC 2407) (I) was currently in phase I/II of clinical trials in 2016 for the treatment of aggressive and advanced solid tumors [1] [2 ...

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4-Aryl-4H-naphthopyrans derivatives: one-pot synthesis ...

Methods. The one-pot, three-component reaction of α or β-naphthol, malonitrile and an aromatic aldehyde in the presence of diammonium hydrogen phosphate was afforded the corresponding 2-amino-4-aryl-4H-benzo[h or f]chromene-3-carbonitrile derivatives, All target compounds were evaluated for inhibition of Src kinase and cell proliferation in breast carcinoma (BT-20) cell lines.

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3-Amino-1-phenyl-1H-benzo[f]chromene-2 .Traduire cette page

01/03/2013 · 3-Amino-1-phenyl-1H-benzo[f]chromene-2-carbonitrile. ... For biological and industrial applications of chromene compounds, see, for example: Ellis & Lockhart (2007 ); Horton et al. (2003 ). For puckering parameters, see: Cremer & Pople (1975 ). For the graph-set analysis of hydrogen bonding, see: Bernstein et al. (1995 ). Experimental Crystal data C 20 H 14 N 2 O. M r = 298.33. Monoclinic, a ...

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Ethyl 3-amino-1-phenyl-1H-benzo[f]chromene-2-carboxyl­ate

Apr 01, 2009 · Comment . 2-Naphthol, substituted benzaldehydes and ethyl 2-cyanoacetate react in the presence of a catalyst to form the ethyl 3-amino-1-aryl-1H-benzo[f]chromene-2-carboxylates; the compounds possess a primary amine group.The crystal structures of several 1-aryl derivatives have been reported (Klokol et al., 1987; Shi et al., 2003a; Shi et al., 2003b; Wang et al., 2003; Zhuang et al., .

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A convenient one-pot synthesis and anxietic activity of 3 ...

A general and easy method for the synthesis of 4,6-disubstituted-3-cyano-2(1H)-iminopyridine or 3-amino-6-chloro-1-aryl-1H-benzo[h]chromen-2-yl cyanide derivatives in the presence of high surface area MgO as a highly effective heterogeneous base catalyst is described.These compounds were synthesized using one-pot component reactions of the properly substituted acetophenone, appropriate ...

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Microwave assisted synthesis of 2-Amino-6 .Traduire cette page

PDF | A convenient and efficient method using microwave assisted synthesis of 4H-benzo[h]chromenes (7 and 8), by the reaction of 4-methoxy-1-naphthol... | Find, read and cite all the research you ...

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2-Amino-4-(4-bromo-phen-yl)-6-meth-oxy-4H-benzo[h]chromene ...

In the title compound, C 21 H 15 BrN 2 O 2, the 14 non-H atoms of the 4H-benzo[h]chromene fused-ring system are approximately coplanar (r.m.s. deviation = 0.129 Å).Within this system, the 4H-pyran ring adopts a flattened half-chair conformation with the methine C atom lying 0.281 (4) Å above the plane of the remaining atoms (r.m.s. deviation = 0.0446 Å).

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3-Amino-1-(4-fluoro­phen­yl)-8-meth­oxy-1H-benzo[f ...

Apr 01, 2013 · The title compound, C 21 H 15 FN 2 O 2, features an approximately planar 1H-benzo[f]chromene fused-ring system (r.m.s. deviation for the 14 non-H atoms = 0.052 Å), with the fluoro­benzene ring being almost perpendicular to this [dihedral angle = 85.30 (7) °].The furan ring has a flattened half-chair conformation, with the methine C atom deviating by 0.132 (2) Å from the plane of .

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The One-step Synthesis of C,D-dihydropyrano[F] Chromene ... · Fichier PDF

This method has the advantages of a simple operation, mild reaction conditions, high yields, by using a less toxic and low cost chemical as a catalyst. Key words: One-step synthesis, Chromene, Environment friendly. In this paper we focus on the preparation of 3-amino-1-phenyl-1H-benzo[f]chromene-2-carbonitrile derivatives 4 (Scheme 1) in ...

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3H-benzo[f]chromene-2-carboxylic acid | SCBT .

Buy 3H-benzo[f]chromene-2-carboxylic acid, a product for proteomics research, from Santa Cruz. Molecular Formula: C14H10O3, Molecular Weight: 226.23

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Studies on the Synthesis of Substituted 2-amino .

The synthesis of several substituted 2-amino-4H-benzo[h]chromene and 3-amino-1H-benzo[f]chromene derivatives was carried out using a one-pot three-component reaction of an arylaldehyde, malononitrile and a naphthol in H 2 O and in the presence of recyclable base supported ionic liquid like-phase as an efficient green catalyst.

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Green and Mechanochemical One-Pot component Synthesis ... · Fichier PDF

Bioactive 2‑amino‑4H‑benzo[b]pyrans via Highly Efficient Amine-Functionalized SiO [email protected] 3O 4 Nanoparticles Preeti Singh,† Priyanka Yadav,† Anupam Mishra, and Satish K. Awasthi* Cite This: ACS Omega 2020, 5, 4223−4232 Read Online ACCESS Metrics & More Article Recommendations * sı Supporting Information ABSTRACT: An ecofriendly, magnetically retrievable amine-functionalized SiO 2 .

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Synthesis, Molecular Properties and Evaluation of .

Background: Chromene, benzochromene and their derivatives have been studied extensively due to their biological and pharmacological activities. Benzochrome...

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Synthesis and Characterization of Novel 2-Amino-Chromene ...

The anti-apoptotic protein Bcl-2 is a well-known and attractive therapeutic target for cancer. In the present study the solution-phase T3P-DMSO mediated efficient synthesis of 2-amino-chromene-3-carbonitriles from alcohols, malanonitrile and phenols is reported. These novel 2-amino-chromene-3-carbonitriles showed cytotoxicity in human acute myeloid

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Design, Synthesis, and Evaluation of Chromen-2-ones as ...

Synthesis, characterization and DFT study of 4H-benzo[h]chromene derivatives. Journal of Molecular Structure 2012, 1018, 171-175. DOI: 10.1016/j.molstruc.2012.03.018. Radineh Motamedi, Saeede Baghbani, Fatemeh F. Bamoharram. Catalytic Method for Synthesis of Benzopyrano[3,2-c]chromene-6,8-dione Derivatives by Heteropoly Acids.

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(1S)-3-Amino-9-hydroxy-1-(3-thienyl)-1H .

The Automated Topology Builder (ATB) and Repository is intended to facilitate the development of molecular force fields for Molecular Dynamics or Monte Carlo simulations of biomolecular systems. Applications include the study of biomolecule:ligand complexes, free energy calculations, structure-based drug design and refinement of x-ray crystal complexes.

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Synthesis of halogen derivatives of benzo[h]chromene and ...

The key intermediate 3-amino-9-chloro-1-(4-halophenyl)-1H-benzo[h]chromene-2-carbonitrile (3) was obtained by treating 4-halobenzylidenmalononitriles (1a–c) and ethyl 4-halobenzylidenmalonates (1d–f) with 4-chloro-1-naphthol (2) in ethanolic piperidine solution. Antimicrobial activity was shown for most of the synthesized compounds.

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